Dailey, Jeffrey

Dailey, Jeffrey W., Tim D. Fryer, Laurent Brichard, Emma S. J. Robinson, David E. H. Theobald, Kristjan La e, et al. Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement. Science 315 (March 2,2007) 1,267-1,270. The researchers report on evidence that indicates the state of dopamine neurotransmission may be an important factor leading to substance abuse problems. 

Source 3 Z. Su and P. Coppens, unpublished, based on X-ray and neutron data of Jeffrey et al. (1987) and private communication. b Millet and Dailey (1972). 

Jeffrey W. Dailey, at the University of Cambridge in the United Kingdom, along with his colleagues, studied rat behavior in combination with chemical analyses and PET. (PET works with laboratory animals as well as with humans.) Of particular interest is an area of the brain called the nucleus accumbens, a region deep in the brain that receives a projection from neurons that use dopamine as a neurotransmitter. Drug use significantly increases this transmission. 

Jeffrey W. Dailey and his colleagues use animal models and imaging to show that the physiological state of dopamine neurotransmission may be an important factor in substance abuse problems. 

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