Daidzin

Ishida et al., 1998 9 week old OVX rats calcium-deficient diet daidzin 10, 25, 50 mg/kg bw by gavage treatment for 28 d starting 7 d after OVX High dose genistin or daidzin prevented bone loss. Daidzin retarded femoral bone loss in a dose-dependent manner... 

Uesugi et al., 2001 11 week old OVX rats tube feeding into the stomach isoflavone glycosides (25, 50 or 100 mg/kg/d) for 4 weeks Daidzin, glycitin and genistin each significantly prevented OVX-induced bone loss at 50 mg/kg/d and reduced urinary excretion of pyridinoline and deoxypyridinoline... 

ISHIDA H, UESUGi T, HiRAi K, TODA T, NUKAYA H, YOKOTSUKA K and Tsuji K (1998) Preventive effects of the plant isollavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficient diet Biol Pharm Bulletin 21, 62-66. 

Upid metabolism abnormality in ovariectomized rats by soy isoflavones, daidzin, genistin, and glycitin. Biol Pharm Bull 24, 368-72. 

Recently, some of the specific faecal bacteria involved in the metabolism of dietary isoflavonoids were isolated (Hur et al., 2000). They have been shown to selectively convert genistin and daidzin to their respective aglycones. One of the isolated bacteria, under anoxic conditions, was further shown to metabolise genistein and daidzein to their respective dihydroxy-genistein and dihydroxy-daidzein. In the case of lignans, enterodiol and enterolactone were shown to be excreted in vivo only in rats harbouring a gut microflora (Rowland et al, 1999). 

HUR H G, LAY J o Jr, BEGER R D, FREEMAN J p and RAFii F (2000) Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin. Arch Microbiol. 174 (6) 422-8. 

Isoflavonoids include the isoflavones genistein and daidzein, which occur mainly as the glycosides genistin and daidzin (see Figure 7.2), respectively, in soybeans and consequently in a wide range of soy-derived foods and to a lesser extent in other legumes. Traditional... 

Hur H-G, Lay JL, Beger RD, Freeman JP, Rafii F. Isolation of human intestinal bacteria metabolising the natural isofiavone glycosides daidzin and genistin. Arch. Microbiol. 174, 422 28, 2000. 

Daidzin and genistin (isoflavones) Stink bug Nezara viridula) 377... 

Variety Daidzin Genistin Daidzein Genistein Total Free CYP3A4 inhibition... 

Pueraria lobata (Willd.) Ohwi. P. pseudo-hirsuta Tang. Ge Gen (Kudzu) (root) Isoflavones, daidzin, diadz.in-4, 7-diglucoside, daidzein, puerarin, xylopurarin, robinin, kaempferol-rhamnoside, fatty acids.12-33-48 Antispasmodic, hypotensive, and stabilizing blood pressure, treat angina pectoris. 

N.A. Daidzin, diadzein, isoflavonoids, puerarin, sterol.99 For colds, influenza, feverish illness, thirst in diabetes, externally for snakebite. 

Daidzin 7,4 -Dihydroxyisoflavone 7- glucoside or daidzein 7-O-glucoside or daidzein 7-O-p-o-glucopyranoside I X ° /° X... 

Figure 11.6.3 Gradient HPLC separation of isoflavone standards (see Basic Protocol 3). Peaks 1, daidzin 2, glycitin 3, genistin 4, malonyldaidzin 5, malonylglycitin 6, acetyldaidzin 7, acetylglycitin 8, malonylgenistin 9, daidzein 10, glycitein 11, acetylgenistin 12, genistein. Conditions Waters Nova-Pak C18 reversed-phase column (150 x 3.9 mm 4-pm i.d. 60 A pore size) mobile phase 1% acetic acid in water (solvent A) and acetonitrile (solvent B) flow rate 0.60 ml/min UV detector 260 nm column temperature 25°C. The dotted line represents the gradient of solvent B.

Xu, Z., Wu, Q., and Godber, S. 2002. Stabilities of daidzin, glycitin, genistin, and generation of derivatives during heating. J. Agric. Food Chem. 50 7402-7406. 

Daidzcin H H OH 7-O-glucosidc of daidzein = Daidzin of genistein = Genistin of glycitein = Glycrtm HO ... 

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