Daidzein toxicity

Sophora subprostrata Chun et T. Chen Shan Dou Gen (root) Matrine, oxymatrine, anagyrine, methylcytisine, sophoranone, sophoranochromene, sophoradin, daidzein.33 This herb is toxic. Against tubercle bacilli, treat intractable ulcerative colitis, antiarrhythmic, anticancer, promotes leukocytosis. 

Genistein and daidzein directly affect testosterone metabolism, reducing the toxic metabolites of testosterone. Genistein, an isoflavone, also seems to slow or prevent the metastasis of invasive cancer cells. It is believed to work by preventing the formation of new blood vessels to cancerous tumors. Histoculture studies of genistein have shown that this phytochemical reduces the growth of prostatic cancer tissue. 

Toxicities of kudzu root are very low daily oral doses of 50-100g in humans have not produced any adverse effects LD50 in mice is 1.6-2.1 g/kg (i. V.) for total kudzu flavonoids and 1 g/kg (i.v.) for puerarin daidzein 0.8 g/kg... 

---