D-Saccharic acid

D-Saccharic acid 1,4-lactone (SAL 5-10 mM), a selective inhibitor of/3-glucuronidase [29], is often included in UGT reactions for improving yield. As /3-glucuronidases and UGTs have different optimal pH ranges, use of SAL in preparative-scale reactions may be avoided. 

D-isoascorbic acid D-mannitol D-mannose D-quinic acid D-ribolactone D-ribose D-saccharic acid D-sorbitol L-sorbose D-xylose (—)-a-Pinene (+)-a-Pinene (—)-/ -Pinene (i )-(+)-pulegone... 

Inhibition buffer 210.1 mg D-saccharic acid-1,4-lactone (10 mM Sigma) is dissolved in 100 ml demineralized water. 

The structural relationship of D-glucuronic acid to D-glucose was established by Fischer and Piloty9 in 1891 when they obtained it by reduction of D-saccharic acid with sodium amalgam. 

XIX). Lactones react like substituted hydroxy acids, provided that the lactone ring is sufficiently stable to resist hydrolysis during the oxidation reaction. Thus, the carbon chain of the 3,6-monolactone (XX) of D-saccharic acid is cleaved between carbon atoms 4 and 6 to yield XXI, which is an ester of glyoxyUc acid with li-threuronic acid... 

D-saccharic acid. (2,3,4,5-tetrahydroxyhexa-nedioic acid tetrahydroxyadipic acid). C00H(CH20)4C00H. The 1,6-dicarboxylic acid formed by the oxidation of D-glucose. 

Definition Calcium salt of D-saccharic acid Empirical C6H8Ca08 4H2O Properties Wh. cryst. powd., odorless very si. sol. alcohol, cold water pract. insol. in chloroform and ether sol. in dil. min. acids, calcium gluconate sol ns. m.w. 320.27 (tetrahydrate)... 

Also interesting is the Mn(II) D-saccharide MOF ([Mn2(sac)2(H20)2] with H2sac = D-saccharic acid) with chiral helicity and redox activity centered on manganese. In this structure hydrophilic channels have been identified and two distinct redox processes (see Fig. 9) have been observed in distilled water but so far not further investigated. 

Fig. 9 Structure of D-saccharic acid and the MOF ([Mn2(sac)2(H20)J with H2sac = D-saeeharie aeid). Also shown are cyclic voltammograms (scan rate 20, 50, 70, 100, 150, 200, 250 mV s ) in distilled water (taken from ref. 77).

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