D-Lysine

L-Lysine monohydrochloride [657-27-2] M 182.7, [a] as above. Likely impurities are arginine, D-lysine, 2,6-diaminoheptanedioic acid and glutamic acid. Crystd from water at pH 4-6 by adding 4 volumes of EtOH. Above 60% relative humidity it forms a dihydrate. 

Indene Picrate. C9H8+C6H307N3 golden yel needles mp 98° very expl in the dry state decomps slowly in air (Beil 6,271 [259]) d-Lysine Picrate. C6Hi4 02N2+C6H307N3 crysts mp, explds on slow heating [Beil 6,... 

Malcolm (1973, 1975) reported possible observable differences between the pressure-area curves of poly(L-alanine) mixed with poly(D-a-amino-n-butyric acid) and the corresponding mixture containing poly(D-alanine). Shafer (1974) observed differences in the film pressure between (/ )-phosphatidyl serine with poly-L-lysine and the corresponding film with poly-D-lysine injected under the film. 

D-Lysine, systematic name, formula, and molecular weight, 2 556t DL-Lysine, systematic name, formula, and molecular weight, 2 556t L-Lysine, systematic name, formula, and molecular weight, 2 556t Lysocellin, 20 120, 137 Lysozyme... 

The relevance of such a diastereomer discrimination to the transport of chiral molecules, such as pharmaceuticals or biochemicals, through hydrophobic barriers, such as cell membranes, is obvious. Furthermore, since poly(DL-lysine) followed the same general pattern of behavior displayed by the other three samples, the observed surface-pressure changes probably were not due to helicalization of the polypeptide. Whereas poly(L-lysine) and poly(D-lysine) form helices with opposite screw sense, the random copolymer poly(DL-lysine) is to a large extent prevented from forming helices. 

The hyperbranched poly( acrylic acid) graft films -C02H-rich interface on polyethylene can be modified by noncovalent methods just like CO2H-rich interfaces of PAA/Au grafts. This was shown by treating deprotonated 3-PAA/PE films with cationic polyelectrolytes like poly-D-lysine, and amine terminated PAMAM dendrimers at pH 7 [31]. Equation 10 illustrates the entrapment of PAMAM dendrimers in a 3-poly(sodium acrylate)/PE film. In these cases, polyvalent entrapment of the cationic electrolyte was evidenced in the ATR-IR spectriun by the appearance of amide C = O and N - H peaks of the guest dendrimer that were not present in the host 3-poly(sodium acrylate)/PE film. 

Fig. 18. The in vivo fluorescence time dependence after a bolus injection of fluorescein labeled poly-D-lysine in a single rat pre-kidney ligation (Normal) and post kidney ligation (Ligated). The solid line is a single exponential fit to the measured data...

This cobalamin-dependent enzyme [EC 5.4.3.4], also called D-a-lysine mutase, catalyzes the interconversion of D-lysine and 2,5-diaminohexanoate. 

Recently, Tanabe has developed a process for the production of D-lysine from L-lysine by successive chemical racemisation and microbial degradation of the remaining L-lysine. 

If placed in water and adjusted to a pH of 7, will the following migrate toward the anode or the cathode if placed in an electrical field (a) Aspartic acid, (b) alanine, (c) tyrosine, (d) lysine, (e) arginine, and (f) glutamine... 

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