L-Leucyl-D-tyrosine

The binding constant of the substrate acetyl-L-leucyl-L-tyrosine methylamide to pepsin (Km) is reported as 2.7 mM and the binding of the inhibitor acetyl-D-tyrosyl-D-leucine methylamide (Kt) as 5.8 mM. The binding shown in Fig. 6 was proposed for the reason that both binding constants are almost identical. This assumption is based upon the idea that the space-filling structure of leucyltyrosine in the L-configuration is similar to that of the reversed sequence, tyrosylleucine, in the D-configuration. A... 

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