D-Fructose 1-phosphate aldolase

Sugiyama, M., Hong, Z.Y., Liang, RH. et al. (2007) D-Fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocyclitols. Journal of the American Chemical Society, 129, 14811-14817. 

D-Fructose-6-Phosphate Aldolase as Catalyst for Iminosugar Synthesis 307... 

Most interestingly, two fructose 6-phosphate aldolase isozymes (transaldolase C (TALC) and D-fructose-6-phosphate aldolase (FSA)) were reported from the E. coli genome and characterized in recombinant form [41]. 

Pig. 6.5.13 d-Fructose-6-phosphate aldolase (FSA) catalyzed aldol additions of DHA to a number of aldehyde acceptors... 

An exception is the dihydroxyacetone (DHA) utilizing aldolases such as the D-fructose-6-phosphate aldolase that also accepts hydroxyacetone, hydroxy-butanone, and glycoaldehyde. Such broad donor tolerance is almost unique among aldolases [8,82]. Aldolases can accept a broad structural variety of aldol acceptors, and this is what makes them highly important for synthetic applications. 

A.L Concia, C. Lozano, J.A. Castillo, T. Patella, J. Joglar, P. Qapes, D-Fructose-6-phosphate aldolase in oiganic synthesis cascade chemical-enzymatic preparation of sugar-related poly-hydroxylated compounds, Chem. Eur. J. 15 (2009) 3808-3816. 

M. Gutierrez, T. Patella, J. Joglar, J. Bujons, P. Qapes, Strucmie-guided redesign of D-fructose-6-phosphate aldolase from E. coli remarkable activity and selectivity towards acceptor substrates by two-point mutation, Chem. Commun. 47 (2011) 5762-5764. 

DIHYDROXYACETONE PHOSPHATE (DHAP)-DEPENDENT ALDOLASES, d-FRUCTOSE-6-PHOSPHATE ALDOLASE (FSA) AND TRANSALDOLASES... 

Concia, A. L., Lozano, C., Castillo, J. A., Parella, T., Joglar, J., and Clapes, R, D-Fructose-6-phosphate aldolase in organic synthesis Cascade chemical-enzymatic preparation of sugar-related polyhydroxylated compounds. Ghent. Eur. J. 2009,15 (15), 3808-3816. 

Garrabou, X., et al.. Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by D-fructose-6-phosphate aldolase. Angew. Chem. Int. Ed., 2009.48(30) 5521-5525. 

Sugiyama M, Hong Z, Liang P-H, Dean SM, Whalen LJ, Greenberg WA, Wong C-H. D-Fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocycUtols. J. Am. Chem. Soc. 2007 129 14811 14817. 

---