Cytosolic calcium mobilization inhibition

Although slightly attenuated, the rise in cytosolic calcium proceeds in the absence of extracellular calcium (as mentioned above), indicating that upon All stimulation calcium is released into the cytosol from an internal pool. The identity of this mobilized internal pool was initially inferred from cellular studies in which treatment with dantrolene inhibited the redistribution of intracellular calcium [39,40], Be-... 

There are three important ADP receptors on the platelet surface (16). The P2X, inotrophic receptor is responsible for rapid influx of calcium into the cytosol. The P2Y, receptor mediates mobilization of calcium through activation of PLC and shape change. The P2Y,2 receptor is coupled to adenyl cyclase inhibition mediated by a G-protein with subsequent decrease in the cAMP The decrease in cAMP stimulates dephosphorylation of VASP that is closely correlated with the GPIIb/llla activation. 

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