CYTOS microreaction system

The Stevens group [20] performed the reaction under microreaction conditions using the previously mentioned CYTOS College System [18]. The main problem with this setup is the formation of crystals (as the final products are crystalline) that leads to clogging of the system. This was circumvented by injection of a fluorinated inert solvent (Fluorinert FC-70) after the micromixing unit and before the RTU, which prevented the clogging and allowed the authors to collect the desired compounds easily by phase separation. 

Another prodrug synthesis using a microfluidic reaction system is that of the antibiotic ciprofloxacin [10], A microreaction system developed by CPC systems (CYTOS) was used as a reaction apparatus. This system is the size of a videotape with a holdup of 1.8 ml. The high surface-to-volume ratio for the mixing section as well as for the temperature-controlled reaction channels allows heat transfer coefficients of up to 2,000 Wm K . The synthesis has demonstrated the potential for faster development, particularly in the preparation of relevant quantities for development studies, such as clinical trials, using the microreaction systems. 

Shwalbe et al. reported the continuous flow Mizoroki-Heck reaction using DMF as a solvent [8], in which rapid catalyst screening and optimization of the reaction conditions were performed using a CYTOS-based microreaction system, which they call SEQUOS. 

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