Cytochrome using single oxygen donor

V.B. Model Systems for Cytochrome P-450 Using Single Oxygen Atom Donors... 

Figure 16 Intermediates involved in alkane oxidation by cytochrome P450. Catalytic cycles involving either O2 and electrons (from NADPH), or a single oxygen atom donor (AO) are shown. Model reactions often use single oxygen atom donors AO such as iodosylbenzene, amine A-oxides and organic or inorganic hydroperoxides or peroxy acids ...

This scheme contains shortcuts. Only these shortcuts could be mimicked catalyti-cally and in an efficient way by many model compounds having a closely related structure. Indeed, Oj activation is difficult and complex, as one can notice on the mechanistic scheme. In particular, iron and manganese porphyrin complexes have been synthesized in order to mimic cytochrome P450 using single oxygen-atom donors such as H2O2, etc. (XO on the scheme). 

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