Cytochrome P450 oxidoreductase POR

Fig. 2.2 Evolutionary origins of the structures of NADPH-cytochrome P450 oxidoreductase POR) and the neuronal NOS (tiNOS) reductase domain cyan), shown by overlays of the ribbon struetures of Desulfovibrto vulgaris flavodoxin (Fid) and spinach ferredoxin-NADP-oxidoreductase FNK). a Structures of Fid and FNR. b POR with flavin mononucleotide FMN) and flavin adenine dinucleotide FAD) highlighted with red sticks. The...

Fig. 2.14 Interface of the NADPH-cytochrome P450 oxidoreductase (POR)-flavin mononucleotide (FMN) domain—P450 2B4 eomplex. The model was generated as previously described, using mutagenesis constraints...

Adachi M, Tachibana K, Asakura Y, Yamamoto T, Hanaki K, Oka A (2004) Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Ant-ley-Bixler syndrome. Am J Med Genet A 128 333-339... 

Fig. 2.5 Top panel, a Model of a complex between P450 and NADPH-cytochrome P450 oxidoreductase (FOR). A complex of P450 (red) and Mol A of the hinge-deletion mutant of POR(ATGEE), denoted as PORT e [53]). the flavin mononucleotide (FMN) domain (blue) and flavin adenine dinucleotide (FAD) domain (yellow)] and an enlarged view showing the relative orientation of the EMN and heme, b and c Open-book representation of molecular surface at the interface of P450 (b) and the EMN domain of POR (c). Five salt-bridge pairs are shown with same let-...

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