Cytidine 5 -monophosphate CMP

The common pyrimidine ribonucleotides are cytidine 5 -monophosphate (CMP cytidylate) and uridine 5 -monophosphate (UMP uridylate), which contain the pyrimidines cytosine and uracil. De novo pyrimidine nucleotide biosynthesis (Fig. 22-36) proceeds in a somewhat different manner from purine nucleotide synthesis the six-membered pyrimidine ring is made first and then attached to ribose 5-phosphate. Required in this process is carbamoyl phosphate, also an intermediate in the urea cycle (see Fig. 18-10). However, as we noted... 

The sugar nucleotides (an uninformative name that has been used for glycosyl nucleotides, or more strictly, glycosyl esters of nucleoside di- or mono-phosphates) were discussed in this Series12 in 1973. Since then, accumulation of new data about these derivatives has continued, and now, about 35 representatives of this class are known to participate in the biosynthesis of polysaccharide chains of bacterial polymers (for a survey, see Ref. 13). These include glycosyl esters of uridine 5 -diphosphate (UDP), thymidine 5 -diphosphate (dTDP), guanosine 5 -diphosphate (GDP), cytidine 5 -diphosphate (CDP), cytidine 5 -monophosphate (CMP), and adenosine 5 -diphosphate (ADP). 

Ni L, Sun M, Yu H, Chokhawala H, Chen X, Fisher AJ. Cytidine 5 -monophosphate (CMP)-induced structural changes... 

Nucleotides, which contain one, two, or three phosphate groups, are named as mono-, di-, or triphosphate derivatives of the nucleosides for example, cytidine 5 -monophosphate (CMP), 5 -di-phosphate, and 5 -triphosphate are the nucleotides derived from cytidine. 

FIGURE 28.5 Typical chromatogram for separation of five nucleotides by ion-pair reversed-phase HPLC method. (1) cytidine 5 -monophosphate (CMP) (2) uridine 5 -monophosphate (UMP) (3) guanosine 5 -monophosphate (GMP) (4) inosine 5 -mono-phosphate (IMP) (5) adenosine 5 -monophosphate (AMP). The concentration of each nucleotide injected onto the column was 15 mg L h (Reprinted from Food Chem., 7A, Ferreira, I. M. P. L. V. O. et al., The determination and distribution of nucleotides in dairy products using HPLC and diode-array detection, 239-244, Copyright 2001, with permission from Elsevier.)... 

CMP Cytidine 5 -monophosphate HPLC High-performance liquid chro-... 

Fig. 4.3.2 Human sialic acid metabolism and genetic defects. -6P -6-Phosphate, -9P -9-phos-phate, CMP cytidine 5 -monophosphate, CTP cytidine 5 -triphosphate, UDP-GlcNAc uridine diphosphate-N-acetyl-D-glucosamine, ManNAc N-acetylmannosamine, NeuAc N-acetylneur-aminic acid, OGS oligosaccharides, SASD sialic acid storage disease...

Scheme L Synthesis of a2,64inked sialyl-N-acetyllactosamine using a one-pot multi-enzyme system with in situ regeneration of CMP-Neu5Ac. Abbreviations for enzymes CSS, CMP-sialic acid synthetase NMK, nucleoside monophosphate kinase PK, pyruvate kinase PPase, pyrophosphatase. Abbreviations for compounds PEP, phosphoenolpyruvate ADP, adenosine 5 -diphosphate ATP, adenosine 5 -triphosphate CMP, cytidine 5-monophosphate CDP, cytidine 5 -diphosphate CTP, cytidine 5-triphosphate LacNAc, N-acetyllactosamine NeuSAc, N-acetylneuraminic acid PPi, inorganic pyrophosphate.

Metal-Nucleoside, -Nucleotide, and-Nucleic Acid Interactions.—The crystal structure of a cadmium derivative of cytidine 5 -monophosphate [Cd(5 -CMP)(H20)]H20 has been reported, in which cadmium is bonded to the N(3) position oh the base, to a phosphate oxygen from each of three other 5 -CMP groups and to a water molecule. In the crystal of bis-(8-azahypoxanthinato)tetra-aquocadmium(ii), the metal is six co-ordinate, two purines being co-ordinated to cadmium through N(7). ... 

Cytidine phosphates cytidine S -monophosphate (CMP, cytidylic acid, M, 323.2), cytidine 5 -diphos-phate (CDP, M, 403.19) and cytidine 5 -triphosphate (CTP, M, 483.16). For structure, see e. g. Pyrimidine biosynthesis. CTP is a precursor of RNA synthesis, while deoxy-CTP is a precursor of DNA synthesis. CDP may be regarded as the coenzyme of phospholipid biosynthesis (see Membrane lipids) (activated choline is CDP-choline). Glycerol and the sugar alcohol, ribitol, are also activated by bonding to CDP (see Nucleoside diphosphate sugars). Reduction of ribose... 

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