Cystic fibrosis alginate-forming bacteria

An additional transferase that uses acetyl-CoA as a substrate sometimes acetylates one mannuronate unit. The disaccharide irnits are then inserted into the growing chain. An additional modification, which occurs after polymerization, is random C5 epimeriza-tion of unacetylated D-mannuronate residues to l-guluronate.136 182 Formation of alginate is of medical interest because infections by alginate-forming bacteria are a major cause of respiratory problems in cystic fibrosis.182... 

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See also in sourсe #XX -- [ ]

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