Cystic fibrosis acute respiratory exacerbations

Bolus intravenous colistin (160 mg in 10 ml of saline tds) has been studied in a phase I open study during acute respiratory exacerbations in adults vvith cystic fibrosis and chronic P. aeruginosa infection patients without total indwelling venous access systems had mild to moderate injection-like pain (34). 

Conway SP, Etherington C, Munday J, Goldman MH, Strong JJ, Wootton M. Safety and tolerability of bolus intravenous cohstin in acute respiratory exacerbations in adults with cystic fibrosis. Ann Pharmacother 2000 34(ll) 1238-42. 

Gold R, Carpenter S, Heurter H, et al. Randomized trial of ceftazidime versus placebo in the management of acute respiratory exacerbations in patients with cystic fibrosis. J Pediatr 1987 111 907-913. 

McGrath L. T., Patrick R., Mallon R, Dowey L., Silke B., Norwood W., and Elborn S., Breath isoprene during acute respiratory exacerbation in cystic fibrosis, Eur. Respir. J., 16, 1065-1069, 2000. 

---