Cysteine string protein

Cysteine string protein (CSP) Cytochrome b561 Peripheral membrane protein that is paimitoylated on >10 cysteines. May have a role in Ca2+ sensitivity of exocytosis. Electron-transport protein required for intravesicular monooxygenases in subsets of secretory vesicles. Required for dopamine- -hydroxylase and peptide amidase activity. 

Synapsins la, lb, Ha, lib Rab3, rabphilin Cysteine string proteins (CSP) Synaptotagmins... 

The question of how DnaJ proteins interact with substrates and mediate their transfer onto Hsp70 partner proteins is not answered for any of the three classes of DnaJ proteins. Some DnaJ homologs have broad substrate specificity, such as E. coli DnaJ and yeast Ydjl, while others have more restricted substrate spectra. In particular the DnaJ proteins of class III may either bind a restricted number of substrates, such as the clathrin-specific auxilin or the kinesin light chain, or they may not bind substrates themselves but rather are positioned in close proximity to substrates. The latter seems to be the case for Dj 1A in the plasma membrane of E. coli (Clarke et al, 1997 Kelley and Georgopoulos, 1997a), Sec63 at the translocation pore in the ER (Corsi and Schekman, 1996 Rapoport et al., 1996), and cysteine string proteins on the surface of neurosecretory vesicles (Buchner and Bundersen, 1997). 

Graham, M. E., Burgoyne, R. D. 2000. Comparison of cysteine string protein (Csp) and mutant alpha-SNAP overexpression reveals a role for Csp in late steps of membrane fusion in dense-core granule exocytosis in adrenal chromaffin cells. J. Neurosci. 20 1281-1289. 

Cysteine string protein (CSP) DCSP-2 GST-FL MAb 49 mouse monoclonal mouse monoclonal... 

Zinsmaier K.E., Eberle K.K., Buchner E., Walter N., and Benzer S. 1994. Paralysis and early death in cysteine string protein mutants of Drosophila. Science 263 977-980. 

Zinsmaier K.E., Hofbauer A., Heimbeck G., Pflugfelder G.O., Buchner S., and Buchner E. 1990. A cysteine-string protein is expressed in retina and brain of Drosophila. J. Neurogenet. 7 15-29. 

Ranjan R., Bronk R, and Zinsmaier K.E. 1998. Cysteine string protein is required for caldum secretion coupling of evoked neurotransmission in Drosophila but not for vesicle recycling. /. Neurosci. 18 956-964. 

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