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Cysteine accessibility scanning

C2 constitutes part of the transducin interaction domain (Fig. IB). Figure 10A shows the sequence in C2, TM3, and TM4 (136-155) that has been investigated by cysteine scanning mutagenesis and SDSL (Ridge et at., 1995 Farahbakhsh et al., 1995). Figure 10B (upper panel) shows the fractional solvent accessibilities for residues in the 136-155 sequence... [Pg.264]

Site-directed mutagenesis, cysteine-scanning accessibility methods, high field NMR, homology modeling, and continued development of structure-activity relationships will no doubt lead to better and better models of the monoamine transporters. These approaches are having the greatest impact on studies of uptake inhibitors, rather than studies of substrates. [Pg.193]

Kurz, L. L., Zuhlke, R. D., Zhang, H. J., andjoho, R. H. (1995). Side-chain accessibilities in the pore of a K- - channel probed by sulfhydryl-specific regents after cysteine-scanning mutagenesis. Biophys. J. 68, 900-905. [Pg.345]

See other pages where Cysteine accessibility scanning is mentioned: [Pg.21]    [Pg.22]    [Pg.22]    [Pg.21]    [Pg.22]    [Pg.22]    [Pg.21]    [Pg.22]    [Pg.22]    [Pg.21]    [Pg.22]    [Pg.22]    [Pg.654]    [Pg.779]    [Pg.34]    [Pg.224]    [Pg.449]    [Pg.220]    [Pg.654]    [Pg.779]    [Pg.22]    [Pg.215]    [Pg.1854]    [Pg.110]   
See also in sourсe #XX -- [ Pg.8 , Pg.22 , Pg.31 , Pg.209 , Pg.211 ]

See also in sourсe #XX -- [ Pg.8 , Pg.22 , Pg.31 , Pg.209 , Pg.211 ]



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