Cysteamine dioxygenase

Cysteamine is oxidized by cysteamine dioxygenase (EC 1.13.11.19) to hypotaurine, which is then oxidized to taurine by an as yet unidentified enzyme. 

Cysteine dioxygenase 2 cysteine sulfinate decarboxylase 3 cysteamine dioxygenase 4 hypotaurine dehydrogenase... 

CYSTEINE DIOXYGENASE AND CYSTEAMINE DIOXYGENASE ACTIVITY IN SOME ANIMAL ORGANS... 

CYS - Cysteine dioxygenase, CYM Cysteamine dioxygenase. Values in micromoles of products per gram of fresh tissue per hour. Each value is the average of three different experimental results which varied by about 10%. 

The problem of regulation is complicated by the metabolic complexity of sulfur amino acids, and the wide variation in organ taurine concentrations between species. The major putative metabolic routes to taurine from cysteine are three These involve the intermediacy respectively of cysteine sulfinic acid, cysteic acid, and cysteamine. The first two utilize the enzyme cysteine sulfinic acid decarboxylase (CSAD), and the latter the enzyme cysteamine dioxygenase (CD). The distribution of these enzymes differ both quantitatively and qualitatively in corresponding organs of various species. Other pathways of taurine biosynthesis have also been proposed. For... 

Cysteamine dioxygenase activity is present in the heart, and the heart has the capability to biosynthesize taurine. The heart can also take up taurine from the circulation. 

Bisnor- 4,6-dithiohexanoate or l,2-dithiolane 3-propanoate CBI covalent binding index CD circular dichroism CD = cysteamine dioxygenase... 

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