Polyhydroxylated cyclopropane

Petrosidae 360-380 500-520 Petrosia, Strongylophora, Xestospongia (= Neopetrosia) Acetylenic derivatives, macro-heterocycles, ve long-chain fatty acids (>4°C), brominated fatty acids, atypical sterols (cyclopropanes, polyhydroxylated, sulfated), atypical glycerol ethers, meroterpenes, aromatic derivatives... 

Aryl- and alkenyl-substituted oxiranes, when submitted to treatment with super-basic reagents, undergo a highly regio- and stereo-selective 3-exo-cyclization leading to cyclopropylmethanol derivatives (Scheme 46). The process has be applied to mono- and di-hydroxy-substituted substrates, thus leading to polyhydroxylated cyclopropanes.78... 

As the glycosides from starfish are steroidal in nature and as some known polyhydroxylated steroids with moderate cytotoxicity have been isolated from these animals, the literature since 1980 dealing with such compounds will be reviewed here. Aside from some monohydroxyste-rols from Echinaster sepositus 646), Acanthaster planci 647) - this being a source of a new cyclopropane sterol Asterias vulgaris 648), and Comasterias lurida 649), the reports deal mainly with polyhydroxylated steroids. 

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