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Cyclopropane-1,1,2-tricarboxylic acid

Esters of l-(4-pentyloxybenzoyl)cyclopropane-2,2,3-tricarboxylic acid 133 have antineoplastic activity. Thus oral application of 100 mg/kg per day to mice for eight days suppressed the growth of transplanted S 37 tumor by 26%, Eq. (53) [184]. [Pg.31]

Ring closure is a common feature of the reaction of sulfur tetrafluoride with cyclopropane-, cyclobutane- and cyclopentanepolycarboxylic acids. This tendency seems to be enhanced by steric crowding. Thus, m,tricarboxylic acid gives a 1 1 mixture of cyclic ether 13 and cis,trims-], 2,3-tris(trifluoromethyl)cyclopropane, whereas cyclopropane-... [Pg.355]


See other pages where Cyclopropane-1,1,2-tricarboxylic acid is mentioned: [Pg.197]    [Pg.127]    [Pg.614]    [Pg.197]    [Pg.994]    [Pg.994]   


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Cyclopropane acids

Cyclopropanes acidity

Tricarboxylates

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