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Cyclooxygenase activity/inhibition angiogenesis

Symbioimine (35) also significantly inhibited cyclooxygenase-2 (COX-2) activity (32%) at 10 pM. Meanwhile, it had only weak inhibitory ability (5%) toward COX-1 at 10 pM [72]. The overexpression of COX-2 has been observed in many kinds of tumors, and its role in carcinogenesis and angiogenesis has been extensively investigated [76,77]. Several COX-2-selective inhibitors, such as rofecoxib, celecoxib, and sulindac, have been developed. Because of its moderate subtype specificity, symbioimine (35) may be useful for the development of new nonsteroid anti-inflammatory drugs (NSAID) to treat COX-associated diseases, such as inflammatory diseases and cancer. [Pg.175]

See other pages where Cyclooxygenase activity/inhibition angiogenesis is mentioned: [Pg.41]    [Pg.583]    [Pg.72]    [Pg.852]    [Pg.306]    [Pg.188]    [Pg.61]    [Pg.330]    [Pg.27]    [Pg.309]    [Pg.247]    [Pg.1453]    [Pg.2351]    [Pg.570]    [Pg.30]    [Pg.101]    [Pg.444]   
See also in sourсe #XX -- [ Pg.133 ]



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Angiogenesis

Angiogenesis activity

Angiogenesis inhibition

Cyclooxygenase

Cyclooxygenase activation

Cyclooxygenase activity

Cyclooxygenases inhibition

Inhibition activity

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