Cyclohexylcarbonyl chloride

Synthesis of cyclohexyl methyl ketone.1 One hundred milliliters of dry benzene and 14.66 g. (0.10 mole) of cyclohexylcarbonyl chloride are poured into a 500-ml. 

For instance. House has shown that in the cyclization of trans-2-phenyl cyclohexylcarbonyl chloride to cis-hexahydrofluorenone, the epimerisation occurred during the acylation and resulted from the formation of an enolate. 

Praziquantel Praziquantel, 2-(cyclcohexylcarbonyl)-l,2,3,6,7,llb-hexahydro-47f-pyrazino [2,la]isoquinolin-4-one (38.1.15), is a derivative of pyrazinoquinoline that is made in two ways [17-19], According to one of them, l-aminomethyl-l,2,3,4-tetrahydroiso-quinoline is alkylated with chloroacetic acid, and then the resulting amine is acylated with cyclohexanecarbonyl chloride to make l-(iV-carboxymethyl-iV-cyclohexylcarbonyl-aminomethyl)-l,2,3,4-tetra-hydroisoquinoline (38.1.14), which is heated at 150°C to give the desired praziquantel. 

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