Cyclohexyl isocyanide reduction

F 4] Cycloaddition with Vinyl Isocyanates. Upon thermolysis in refluxing benzene, 2,5-dihydro-2,2-dimethyl-5,5-bis-(propylthio)-l,3,4-oxadiazole yields the bis(propylthio)carbene precursor, which reacts as a 1,1-dipole equivalent in [1 -E 4] cycloaddition reactions with various vinyl isocyanate substrates leading to highly functionalized adducts such as hydroindolones (eq 1). Reductive desulfurization with Raney nickel yields the enamide or the fully reduced system (eq 2). Cyclohexyl isocyanide also behaves as a 1,1-dipole equivalent in [1 -E 4] cycloadditions with vinyl isocyanates, however the adducts are less functionahzed. ... 

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