Cycloalkanols, synthesis

Cycloaddition reactions, 162-165, 197-198 component analysis, 168 Diels-Alder, 162, 198 ethylene + ethylene, 198 orbital correlation diagram, 198 stereochemistry, 162-163 Cycloalkanols, synthesis, 277 Cyclobutadiene barrier, 91 ground state, 91 point group of, 5 self-reactivity, 97 SHMO, 151 structure, 309-310 Cyclobutane... 

Scheme 18. Malacria s cycloalkanol synthesis via radical addition to aldehyde...

Cycloahphatic amine synthesis routes may be described as distinct synthetic methods, though practice often combines, or hybridi2es, the steps that occur amination of cycloalkanols, reductive amination of cycHc ketones, ring reduction of cycloalkenylarnines, nitrile addition to ahcycHc carbocations, reduction of cyanocycloalkanes to aminomethylcycloalkanes, and reduction of nitrocycloalkanes or cycHc ketoximes. 

Arylrhodium species undergo facile intermolecular 1,2-addition across carbon-carbon triple bonds, with the resulting alkenyl rhodium intermediate providing an entry point for further cascade reactions [121]. As an example, Hayashi applied this concept to the asymmetric synthesis of a number of cycloalkanols 157 starting from ynals 155 and arylboronic acids (Scheme 8.43) [122]. TransmetaUation of the... 

Scheme 5.25 Synthesis of cycloalkanones by P450 BM3 mutants and ADH. The ADH converts intermediate cycloalkanols to cycloalkanones with concomitant NADPH regeneration (ADH also uses 2-propanol for NADPH regeneration).

N., Gotor-Fernandez, V., Gotor, V., Burguete, M.I., Garcta-Verdugo, E., and Luis, S.V. (2012) Stereoselective chemoenzymatic synthesis of enan-tiopure 2-(l H-imidazol-yl)cycloalkanols under continuous flow conditions. 

Another method for synthesis of aminomethyl cycloalkanols involves reduction of the adducts of nitromethane and cyclic ketones ... 

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