Cycloaddition of 3-acyloxy-l,4-enynes

Shu, X., Li, X., Shu, D., Huang, S., Schienebeck, C. M., Zhou, X., Robichaux, P. J., Tang, W. (2012). Rhodium-catalyzed intra- and intermolecular [5 -I- 2] cycloaddition of 3-Acyloxy-l,4-enyne and aUcyne with concomitant 1,2-acyloxy migration. Journal of American Chemical Society, 134, 5211-5221. 

Synthesis of functionalized resorcinols by rhodium-catalyzed [5+1] cycloaddition of 3-acyloxy-l,4-enynes with CO... 

In 2010, Malacria and coworkers [17] reported that resorcinol derivatives can be synthesized through a rhodium-catalyzed [5+1] cycloaddition of 3-acyloxy-l,4-enynes with CO in moderate to good yields (Scheme 17.17). Then these highly functionalized resorcinol derivatives could be transformed to the couesponding biochemically important resorcinols simply through saponification. It was found that the Z double bond isomer was not reactive toward the carbonylative cyclization. 

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