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Cyclo-oxygenase inhibition with indomethacin

Figure 4.8 PAF (10 ng) bolus injection causes vasodilation in isolated rat lungs perfused with blood at constant flow. This vasodilation is inhibited by CV3988 (I0 molL ) a PAF receptor antagonist but not by the cyclo-oxygenase inhibitor, indomethacin... Figure 4.8 PAF (10 ng) bolus injection causes vasodilation in isolated rat lungs perfused with blood at constant flow. This vasodilation is inhibited by CV3988 (I0 molL ) a PAF receptor antagonist but not by the cyclo-oxygenase inhibitor, indomethacin...
Fig. 5. Mechanism of action of corticosteroids and a non-steroidal anti-inflammatory drug (indomethacin) on cellular metabolism of arachidonic acid. Treatment with corticosteroids induces synthesis of lipomod-ulin or macrocortin, which inhibits the release of arachidonic acid from phospholipids. Indomethacin inhibits the enzyme fatty acid cyclo-oxygenase and thus the formation of all prostaglandins and thromboxanes. Fig. 5. Mechanism of action of corticosteroids and a non-steroidal anti-inflammatory drug (indomethacin) on cellular metabolism of arachidonic acid. Treatment with corticosteroids induces synthesis of lipomod-ulin or macrocortin, which inhibits the release of arachidonic acid from phospholipids. Indomethacin inhibits the enzyme fatty acid cyclo-oxygenase and thus the formation of all prostaglandins and thromboxanes.

See other pages where Cyclo-oxygenase inhibition with indomethacin is mentioned: [Pg.153]    [Pg.155]    [Pg.169]    [Pg.73]    [Pg.233]    [Pg.862]    [Pg.200]    [Pg.563]    [Pg.17]    [Pg.17]    [Pg.18]    [Pg.73]    [Pg.78]    [Pg.108]    [Pg.141]    [Pg.160]   
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