Cyclization of nitroketone

With this encouraging precedent, a similar approach was investigated in the Hrst-generation synthesis of ABT-546 (Figure 4). The Michael addition was again carried out in the presence of catalytic base. The reductive cyclization of nitroketone 9 was carried out employing modified conditions to yield directly the trans-trans pyrrolidine, 10. However, despite significant effort, only tartaric acid was found to resolve this pyrrolidine, and then the optically enriched product was obtained with low recovery. 

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See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , , ]

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