Cyclic Dipeptides as Organogelators

We proposed the following working hypotheses for the development of gelators  

Cyclo(dipeptide)s prepared from the same amino acid always give crystals, but not gels. In general, cyclo(dipeptide)s consisting of different amino acids (e.g., neutral and acidic) are superior as gelators to those containing two neutral amino acids. 

The cyclo(dipeptide) 75 was prepared from the commercially available artificial sweetener Aspartame by a one-pot reaction according to the following reactions. The amount of 75 necessary to gel one liter of methanol, ethanol, acetone, ethyl acetate, benzene, toluene, tricaprylin, triolenein, soybean oil and silicone oil are 44 g, 28 g, 28 g, 23 g, 10 g, 3 g, 15 g, 15 g, 13 g and 2 g, respectively. 

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