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Cyclic dienediyne

Suffert J, Toussaint D (1997) Synthesis of a Cyclic Dienediyne Related to the Maduropeptin Chromophore. Tetrahedron Lett 38 5507... [Pg.452]

A particularly interesting application of this protocol, in conjunction with the direct cross-coupling with terminal acetylenes is shown in Scheme 5-2. Here, the first coupling occurs between the alkynyltin reagent 50 and the cyclized palladium intermediate 49 and is followed by the second direct coupling with the terminal acetylene 52 at the vinyl bromide moiety to yield unsymmetrical cyclic dienediyne 53 [32]. [Pg.117]

Scheme 5-2 Synthesis of unsymmetrical cyclic dienediyne 53 by stepwise cross-coupling reactions. Scheme 5-2 Synthesis of unsymmetrical cyclic dienediyne 53 by stepwise cross-coupling reactions.
A mixture of the ten-membered cyclic cw-diol 648 and its trans- om v is obtained from the enediyne dialdehyde 647. A new family of hydrocarbon rings, the three skipped cyclic C12H12 dienediynes 649 - 651, has been described. These compounds were prepared from dilithium derivatives of enediynes and diiodo- or dibromoalkenes as shown in Scheme 6. Treatment of 651 with CpCo(CO)2 gave the cobalt sandwich complex 652 ". ... [Pg.362]

The novel 10-membered ring dienediynes 6, which are related to neocarzinostatin, have been synthesized (see also Vol. 26, p.302) starting from D-xylose, via furanose 4 and the acetylenic diol 5 (Scheme 2). Interestingly, direct reduction of 4 using sodium borohydride failed because of formation of a stable cyclic boronic ester [H,B(OR)j ]. This problem was... [Pg.312]


See other pages where Cyclic dienediyne is mentioned: [Pg.230]    [Pg.230]    [Pg.112]    [Pg.87]   
See also in sourсe #XX -- [ Pg.210 ]

See also in sourсe #XX -- [ Pg.210 ]




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