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Cyclase Aromatic polyketide

Figure 6 (A) Reactions catalyzed by aromatic cyclases and aromatases. These enzymes control the diverse cyclization patterns of aromatic polyketides and in general display high regioselectivity and substrate specificity. (B) Examples of known products with different cyclization patterns that are accessible via the thioesterase (TE) domain of DEBS. Figure 6 (A) Reactions catalyzed by aromatic cyclases and aromatases. These enzymes control the diverse cyclization patterns of aromatic polyketides and in general display high regioselectivity and substrate specificity. (B) Examples of known products with different cyclization patterns that are accessible via the thioesterase (TE) domain of DEBS.
B Shen, RG Summers, E Wendt-Pienkowski, CR Hutchinson. The Streptomyces glaucescens TcmKL polyketide synthase and TcmN polyketide cyclase genes govern the size and shape of aromatic polyketides. J Am Chem Soc 117 6811-6821, 1995. [Pg.466]


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See also in sourсe #XX -- [ Pg.402 , Pg.410 , Pg.419 , Pg.433 , Pg.434 , Pg.435 , Pg.436 ]




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