Cyanohydrins Ritter reaction

Reports of five-membered ring formation involving this mechanism remain unauthenticated. Formation of an oxazolidinone product from Ritter reaction of cyclohexanone and cyclohexanone cyanohydrin has been shown by Ducker to result from an alternative pathway. Although 4-methyl-3-pentenonitrile did undergo intramolecular cyclization, this did not involve pyrrolidone formation. Rather a novel dimeric process took place, leading to formation of a monocyclic (74) and a bi-cyclic (75) product. The latter was readily ring opened to (74) using silver oxide and water (Scheme 37). 

Cyanohydrins and ethers. The react catalyzed, so that it can be used to different Dibutyltin dichloride can be used as a cal Trimethylsilyl bis(fluorosulfonyl)imide is derivatization at -78° (11 examples. 84-989 Ritter reaction. A combination of V hydroxy group to a formamido function. 

D-Glucose orthoesters of complex alcohols can be easily obtained with the help of silver salicylate Alcohols and amines can be conveniently prepared from olefins by ozonization-reduction and ozoni-zation-reductive amination respectively without isolation of intermediates Inverted amines can be obtained from optically-active alcohols through stereospecific formation of N-alkylphthalimides 3-Methoxy-l-phenyl-l-propyne has been used as starting material for the synthesis of a,/ -unsatd. carbonyl compounds through allenic di-carbanions a-Ketocarboxylic acids can be easily prepared from cyanohydrins through a Ritter reaction... 

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