Cyanogen mass spectrometry

The major fragmentation in mass spectra of 1,2,5-oxadiazoles is attributed to the loss of nitrile and nitrile oxide or expulsion of NO. The conversion of 3,4-dicyano-l,2,5-oxadiazole-2-oxide (3,4-dicyanofuroxan) 10 to cyanogen iV-oxide 11 (Equation 5) was investigated under the conditions of collisional activation (CA) and neutralization-reionization (NR) mass spectrometry. Flash vacuum thermolysis mass-spectrometry (FVT-MS) and flash vacuum thermolysis infra-red (FVT-IR) investigations of furoxans 10, 12, and 13 reveal that small amounts of cyano isocyanate accompany the formation of the main thermolysis product 11 <2000J(P2)473>. 

So far, all efforts to generate, isolate and characterize heterofuUerenes via Kratsch-mer-Huffman vaporization of graphite in the presence of hetero-element-containing compounds such as boron nitride (BN) or cyanogen (CN)2 have failed. An alternative route for the direct formation of heterofuUerenes is cluster rearrangement within exohedral fullerene derivatives such as iminofullerenes and azafuUeroids. The first hints of success by this approach were obtained from mass spectrometry investigations of the cis-l-diazabishomo[60]fullerene 3 [12], the n-butylamine adduct 4 [12] the 1,2-epiminofullerene 5 [11] and the cluster opened ketolactam 6 [2]. 

Recently Fallante et al. (200) reported that GSH S-transferase had been Imsioblllzed on a cyanogen bromide activated Sepharose gel, by a procedure similar to that discussed above for Immobilization of UDP-glucuronyltransferase (39), and used successfully for synthesis of GSH conjugates. A variety of substrates (Table VIII) were conjugated with this system and the products were characterized by chromatographic methods and FAB mass spectrometry. 

Dreifuss PA, Wood GE, Roach JA, Brumley WC, Andrzejewski D, Sphon JA. Field desorption mass spectrometry of cyanogenic glycosides. Biomed Mass Spectrom. 1980 7 201-4. 

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