Cyanobacterial circadian clock

CYANOBACTERIAL KaiABC CIRCADIAN CLOCK Table 13-1. Structures of cyanobacterial circadian clock proteins... 

The US National Institutes of Health (grant ROl GM073845) supports our work on the cyanobacterial circadian clock. We thank our collaborators at Vanderbilt University, Drs. Carl H. Johnson and Phoebe L. Stewart for sharing their insight. 

Golden, S.S. (2004). Meshing the gears of the cyanobacterial circadian clock. Proc. Natl. Acad. Sci. USA 101, 13697-13698. 

Hayashi, F., Suzuki, H., Iwase, R., Uzumaki, T., Miyake, A., Shen, J.-R., Imada, K., Furukawa, Y., Yonekura, K., Namba, K., and Ishiura, M. (2003). ATP-induced hexameric ring structure of the cyanobacterial circadian clock protein KaiC. Genes to Cells 8, 287—296. 

Ivleva, N.B., Gao T., LiWang A.C., and Golden, S.S. (2006). Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock. Proc. Natl. Acad. Sci U.S.A., 103, 17468-17473. Iwasaki, H., Taniguchi, Y., Kondo, T., and Ishiura, M. (1999). Physical interactions among circadian clock proteins, KaiA, KaiB and KaiC, in cyanobacteria. EMBO J. 18, 1137-1145. 

Kitayama, Y., Iwasaki, H., Nishiwaki, T., and Kondo, T. (2003). KaiB functions as an attenuator of KaiC phosphorylation in the cyanobacterial circadian clock system. EMBO J. 22, 1-8. 

Schmitz, O., Katayama, M., Wilhams, S. B., Kondo, T., and Golden, S.S. (2000). CikA, a bacteriophytochrome that resets the cyanobacterial circadian clock. Science 289, 765-768. 

PROTEIN-PROTEIN INTERACTIONS IN THE CYANOBACTERIAL KaiABC CIRCADIAN CLOCK... 

Three-dimensional structures based on crystallographic data and NMR data from solutions are available for all three Kai proteins from various cyanobacterial systems (Johnson Egli, 2004 Golden, 2004) (Table 13-1). With regard to a structural characterization, the components of the cyanobacterial clock are the best studied, such that far more is known about them than the cogs of the eukaryotic circadian clocks... 

An intriguing feature of the cyanobacterial KaLABC circadian clock is that analysis of the structure and function of the central timer requires no concern with input and output. Beyond an understanding of how three proteins are able both to sustain a stable oscillation with a period of 24 h and to do... 

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