Cyanidin 3-0 sambubioside

Catechol-O-methyltransferase (COMT EC 2.1.1.6) is located in many tissues and catalyzes the methylation of polyphenols. The methylation is a well-established pathway in the metabolism of flavonoids such as those that undergo 3, 4 -dihydrox-ylation of ring B excreted as 3 -0-methyl ether metabohtes in rat bile. " Recently, the apparent methylation of both cyanidin-3-glucoside and cyanidin-3-sambubioside (cyanidin is an anthocyanin with a 3, 4 -dihydroxylation of ring B) to peonidin-3-glucoside and peonidin-3-sambubioside was reported in humans. In rats, this transformation occurred mainly in the liver and was catalyzed by COMT."°... 

Saito, N. et al., Acylated cyanidin 3-sambubioside-5-glucosides in Matthiola incana, Phytochemistry, 38, 1027, 1995. 

Cyanidin-3-glucoside, Cyanidin-3-sambubioside Elderberry Human 56, 14, 15, 57, 26... 

As many berries, the fruits of Sambucus nigra (L.) contain large amounts of flavonoids with different stractures, mostly anthocyanins (mainly cyanidin-3-glucoside and cyanidin-3-sambubioside) and small quanities of flavonols and flavonol ester. 

Andersen, 0.M., Aksnes, D.W., Nerdal, W., Johansen, O.P., Structural elucidation of cyanidin-3-sambubioside and assignments of the H and C NMR resonances through two-dimensional shift-correlated NMR techniques, Phytochem. Anal, 1991, 2, 175-183. 

The reports on anthocyanins from Anemone coronaria Pulsatilla cernua and Ranunculus asiaticus reveal structures that are very different from the anthocyanins described above. Many of these latter pigments are based on lathyroside or sambubioside residues located at the 3-hydroxyl of delphinidin, pelargonidin, or cyanidin (Table 10.2). Among these, four unusual anthocyanins containing the acyl moiety tartaryl have been isolated from Anemone coronaria Six of the anthocyanins in this plant have a glucur-onoside in the 3 -position. 

---