Cyanides prebiotic systems

These experiments were, however, not completely accepted by some chemists working in the area of prebiotic chemistry these critics were unhappy with some synthetic conditions used, such as the KCN concentrations (0.1-0.2 M at 373 K). They felt that cyanide in such concentrations would have been relatively rapidly hydrolysed at 373 K in addition, CO pressures of 75 atm were considered incommensurate with real conditions in hydrothermal systems. 

There are two general approaches to the construction of the purine ring system. Additionally, a category which can be defined as one pot methods, are adaptations of the type of process that probably took place in prebiotic times, when simple molecules, such as hydrogen cyanide and ammonia, are believed to have combined to give the first purines. 

---