Curtin-Hammett principle, application

Application of the Curtin-Hammett Principle would suggest that the different ground state conformers have minimal influence on the product composition. It is the difference in activation energies for the two different isomers that controls the reaction, and the diastereomeric transition states would be attained from either ground state conformation. 

Curtin-Hammett principle, 23 industrial applications, 8, 26 mechanism, 21 phosphine ligands, 7, 18 reaction conditions, 18 scope and limitations, 27 Wilkinson complex, 17 Rhodium-catalyzed olefin isomerization ab initio calculations, 110... 

The applicability of the Hammond postulate and the Curtin-Hammett principle was discussed in the review of Manuilov and Barkhash (1990) on the mechanism of deamination. This principle allows evaluation of the effect of conformational changes on the reactivity of compounds A and A forming B and B in the kinetic system (7-40), in which the steps with rate constants k and k, may be monomolecular or bimolecular (with a reagent R) A and A are conformers of the starting material. 

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