Cularine alkaloids cancentrine type

Early reports on simple cularines oxygenated at the 4 and 5 positions termed them isocularines, or cancentrine-type cularines, because of their analogous substitution pattern to that of the alkaloid cancentrine. To simplify nomenclature, we refer to them as 4, 5 -substituted cularines. 

Campello MJ, Castedo L, Sad JM, Suau R, Vidal MC (1982) Cancentrine-type cularine alkaloids sarcocapnine and oxosarcocapnine. Tetrahedron Lett 23 239—240 Castedo L, Suau R, Mourino A (1976) A revised structure for pontevedrine. Tetrahedron Lett 501-502... 

C(14) or C(10)-to-nitrogen bonding arrangement. The position of the acetoxy-group in (316 R = Ac) and thus the hydroxy-group in cancentrine was determined by examination of their n.m.r. spectra and by n.o.e. measurements. Cancentrine is a unique dimeric alkaloid constructed from morphine and cularine subunits and represents a formidable challenge for biogenetic-type synthesis. 

From Dicentra canadensis Walp. three alkaloids of the dimeric type were isolated cancentrine (cularine-morphine dimer), which was originally... 

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See also in sourсe #XX -- [ ]

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