CuAAC for the Synthesis of Dendrimers

CuAAC reactions. However, activation/deprotection steps and long reaction times (up to 30h per coupling reaction) were still needed. 

Hawker and Wooley later extended this CuAAC approach to prepare azide- or alkyne-terminated Frechet-type dendrimers via a divergent strategy (Joralemon et al., 2005). 

The versatility of the concept was also demonstrated for the synthesis of Frechet-type dendrimers by sequential etherification and CuAAC reactions starting from a triphenol core, using AB2 and CD2 types of monomers (Antoni et al., 2007). Because of the simplicity of this strategy, a wide variety of other macromolecular architectures, including star-shaped polymers and hyperbranched polymers, could be easily synthesized with unique characteristics that are tuned by the nature of the monomers. 

Although CuAAC allows for the efficient synthesis of dendritic structures, it should be noted that click chemistry has demonstrated its highest impact for the derivatization or functionalization of well-known dendrimers with bioactive compounds, UV-active compounds or ferrocenyl units. For the detailed description of these topics, we refer to literature (Malkoch et al., 2005 Vestberg et al., 2007). 

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