Cryptolepis Cryptolepine

Cryptolepine [root] Cryptolepis sanguinolenta, DNA (intercalation) (TOPII)... 

Cryptolepine (Ranunculaceae) Cryptolepis sanguinolenta, TOPII (formation of cleavable... 

Dean, Karen. "Cryptolepine Analogs" and "Cryptolepis." HerbalGram, no. 42, spring 1998, page 21. 

Ablordeppy SY, Hufford CD, Bourne RF, Dwuma-Badu D (1990) Proton NMR and carbon-13 NMR assignments of cryptolepine, a 3 4-benzo-d-carboline derivative isolated from Cryptolepis sanguinolenta. Planta Med 56 416-417 Alam M, Mroue M (1991) Crooksiine, a bisindole alkaloid from Haplophyton crooksii. Phytochemistry 30 1741-1744... 

Cryptolepine (47) from the roots of Cryptolepis sanguin-olenta (Asclepiadaceae), is highly active against Plasmodium falciparum. The in vitro IC50 value for this alkaloid is 0.03 JLg/ml, compared to 0.07 xg/ml for chloroquine, a common antimalarial drug (Phillipson et al., 1993). Extracts of the roots of the plant also are used to treat patients in some Southeast Asian countries. 

Struct, unknown. Mol. formula not reported. Co-occurs with Cryptolepine and Quindoline (see 10/f-Indolo[3,2-6]quinoline, 1-00134). Could possibly be identical with the recently isolated Isocryptolepine. Alkaloid from roots of Cryptolepis sanguinolenta (Asclepiadaceae). Mp >300°. 

Recently a complement-modulatory activity has been reported for a series of alkaloids isolated from Cryptolepis sanguinolenta (Lindl.) Schlechter (Periplocaceae). The monomeric alkaloids cryptolepine (tested as its hydrochloride) (62), quindoline (63), and hydroxycryptolepine (64) exhibited a dose-dependent inhibitory effect on the classical pathway [38]. The activity (% inhibition) at a concentration of 1 mM... 

The latter alkaloid is a violet base obtained from Cryptolepis species (Asclepiadaceae) which with selenium gave quindoline which had already been prepared 45 years before. An efficient biogenetic type synthesis of cryptolepine was from indoxyl and o-methylamino benzaldehyde in weakly acidic medium. 

Cryptolepine is an indoloquinolone alkaloid isolated from Cryptolepis sangui-nolenta (Asclepiadaceae) which is widely used traditionally in folklore medicine in many parts of the world for the management, and/or treatment of a plethora of human ailments, including diabetes mellitus. This compound... 

---