2,2,2-cryptand

Synthesis by high-dilution techniques requires slow admixture of reagents ( 8-24 hrs) or very large volumes of solvents 100 1/mmol). Fast reactions can also be carried out in suitable flow cells (J.L. Dye, 1973). High dilution conditions have been used in the dilactam formation from l,8-diamino-3,6-dioxaoctane and 3,6-dioxaoctanedioyl dichloride in benzene. The amide groups were reduced with lithium aluminum hydride, and a second cyclization with the same dichloride was then carried out. The new bicyclic compound was reduced with diborane. This ligand envelops metal ions completely and is therefore called a cryptand (B. Dietrich, 1969). 

Fig. 7. Crown type and analogous receptor molecules of different varieties (1) crown ethers (2) cryptands (3) a podand (4) a spherand and (5) the natural...

The match between crown cavity diameter and cation diameter is obvious from Table 3 showing that, eg, and 12-crown-4 (la) or, respectively and 18-crown-6 (Ic) correspond. Similar are the cryptands of gradually increasing cavity size [2.1.1], [2.2.1] and [2.2.2] for and... 

Fig. 11. Receptor molecules (cryptands) having hetero (nonoxygen) donor atoms (7) or endo-functional acidic sites (8) in the framework.

Fig. 3. Crown compounds/cryptands and analogous inclusion hosts. (1 4) Crown macro rings bicyclic cryptands (5) [37095-49-17, (6) [31250-06-3J, (7) [31364-42-8] (8) [23978-09-8]-, (9) spherical cryptand [56698-26-1]-, (10) cylindrical cryptand [42133-16-4]-, (11) apodand [57310-75-5]-, and (12) a spherand...

Podates AcycHc analogues of crown ethers /coronands and cryptands (podands, eg, (11) (30) are also capable of forming inclusion compounds (podates) with cations and uncharged organic molecules, the latter being endowed with a hydrogen bond fiinctionahty. Podates normally are less stable than coronates and cryptates but have favorable kinetics. 

A method for the polymerization of polysulfones in nondipolar aprotic solvents has been developed and reported (9,10). The method reUes on phase-transfer catalysis. Polysulfone is made in chlorobenzene as solvent with (2.2.2)cryptand as catalyst (9). Less reactive crown ethers require dichlorobenzene as solvent (10). High molecular weight polyphenylsulfone can also be made by this route in dichlorobenzene however, only low molecular weight PES is achievable by this method. Cross-linked polystyrene-bound (2.2.2)cryptand is found to be effective in these polymerizations which allow simple recovery and reuse of the catalyst. 

In 1967, DuPont chemist Charles J. Pedersen (21) discovered a class of ligands capable of complexing alkaU metal cations, a discovery which led to the Nobel Prize in Chemistry in 1987. These compounds, known as crown ethers or cryptands, allow gready enhanced solubiUty of sodium and other alkaU metals in amines and ethers. About 50 crown ethers having between 9—60 membered oligoether rings were described (22). Two such stmctures, dibenzo-18-crown-6 (1) and benzo-9-crown-3 (2), are shown. 

Often poly(ethylene glycol)s or derivatives thereof can be used instead of crowns or onium salts advantageously, although their catalytic activity frequently tends to be somewhat lower. The possible toxicity of crowns and cryptands and the price difference between these compounds and onium salts (100 1 to 10 1) are other important factors to be considered. Thus (1) [17455-13-9] (2) [14187-32-7] and (3) [16069-36-6] and cryptands are used more often in laboratory work, whereas onium salts are more important for industrial processes. 

Cryptand, iodonium complex equilibrium constant, 7, 746 (80JA6574)... 

Cryptands, 7, 731-761 alkali metal complexes NMR, 7, 740 reactivity, 7, 743-744 alkaline earth complexes reactivity, 7, 743-744 anion complexes, 7, 747-748 applications, 7, 753-761 as biological models, 7, 753-754 bis-tren... 

H-1,3,2- Diazaborole, 1,2-dihydro-reactions, 1, 641 synthesis, 1, 639, 640 transition metal complexes, 1, 641 Diazadiborine, tetrahydro-semi-empirical calculations, 1, 632 Diaza[2.2.2]cryptand synthesis, 7, 750 Diazacryptands bispyridine... 

The need for simple descriptions of complicated organic ligands has led to the evolution of some trivial nomenclature systems, such as those for crown ethers (e.g. 76) 72AG(E)16) and cryptands 73MI10200), which have become quite elaborate 8OMII0200). These systems are intended primarily to indicate topology, and the positions of potential donor atoms, and are not particularly appropriate for general use. 

Synthesis of diaza-potyoxa-macrobicyciic compounds (cryptands). 

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