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Crown ethers enolate reactivity, effect

The effects of the counterion on the reactivity of the enolates can be important Reactivity Li+ < Na+ < K+ < ITiN+ addition of crown ethers... [Pg.79]

One of the general features of the reactivity of enolate anions is the sensitivity of both the reaction rate and the ratio of C- versus O-alkylation to the degree of aggregation of the enolate. For example, addition of HMPA frequently increases the rate of enolate alkylation reactions. Use of dipolar aprotic solvents such as DMF and DMSO in place of the THF also leads to rate acceleration. These effects can be attributed, at least in part, to dissociation of the lithium enolate aggregates. Similar effects are observed when crown ethers or similar cation-complexing agents are added to reaction mixtures. [Pg.428]

See other pages where Crown ethers enolate reactivity, effect is mentioned: [Pg.79]    [Pg.79]    [Pg.446]    [Pg.614]    [Pg.91]    [Pg.323]    [Pg.443]    [Pg.443]   
See also in sourсe #XX -- [ Pg.20 ]



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