Crossover wrap-around

Taken together, the hydration propensity of amide and carbonyl and the dehydration-induced strengthening of their electrostatic association represent two conflictive tendencies, suggesting that there must be a crossover point in the dehydration propensity of a backbone hydrogen bond [15]. If the bond is poorly wrapped by a few nonpolar groups that cluster around it, then hydration of the paired amide... 

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