Crosslinks distance

N-terminal actin-binding domains and in the spectrin repeats that form the rod domains (Davison and Critchley, 1988). The spectrin repeats are found in distinct multiples in each protein, resulting in a characteristic actin crosslinking distance. a-Actinin contains four repeats, /3-spectrin contains 17, a-spectrin contains 20, and dystrophin contains 24. The sequences of some spectrin repeats of a- and /3-spectrin are similar in many ways to the four repeats present in a-actinin (Dubreuil, 1991). Within the cell, a-actinin and spectrin dimerize, although the spectrins interact further to generate a functional tetramer (Fig. 1). Most notable is that the ends of the native spectrin tetramer involved in the dimerization event show remarkable similarity to the rod domain repeats of a-actinin that also mediate dimer formation. 

Degree of Crosslinking (%) Distance Between Crosslinked Sections (A) Maximum Volume (mLg->)... 

Fig. 5. Magnified cross section of cotton fibers after intrafiber polymerization of methactylate. a. Fiber crosslinked in unswollen state to give increased resiliency v en dry. b. Fiber not crosslinked. (Distance between marks is 1 p) (44)...

No. Ingredients Chemical classification Nature at 293 K Density, g/cm Mean crosslink distance, S, nm... 

Properties and Failure of Polymers with Tailored Distances Between Crosslinks... 

In summary, the binding models first show a fraction of SB A or VML molecules that bind to Tn-PSM and jump between different aGalNAc residues of the mucin (Fig. 3A). As the number of bound lectin molecules increases, the affinity of the lectin decreases because of shorter diffusion distances on the mucin chain due to steric crowding and crosslinking by multiple bound lectin molecules (Fig. 3B and C). Finally, upon saturation binding, full lectin-mediated crosslinking of the complexes takes place (Fig. 3D). 

Figure 4.1 The general design of a homobifunctional crosslinking agent. The two reactive groups are identical and typically are located at the ends of an organic spacer arm. The length of the spacer may be designed to accommodate the optimal distance between two molecules to be conjugated.

Thermo Fisher). The small cross-bridge, built from a benzoic acid group, provides crosslinking ability at short intermolecular distances. Reaction of one protein via the NHS ester end of the crosslinker provides a stable derivative that can be incubated with a target molecule and then photolyzed to effect the final conjugation (Figure 5.20). 

Here, a is the elongation ratio of the polymer chains in any direction and (r/j1/2 is the root-mean-square, unperturbed, end-to-end distance of the polymer chains between two neighboring crosslinks (Canal and Peppas, 1989). For isotropically swollen hydrogel, the elongation ratio, a, can be related to the swollen polymer volume fraction, u2,j> using Eq. (11). 

The unperturbed end-to-end distance of the polymer chain between two adjacent crosslinks can be calculated using Eq. (12) where Cn is the Flory... 

In Eq. (13) Mr is the molecular weight of the repeating units from which the polymer chain is composed. Finally, when one combines Eqs. (10) through (13), the correlation distance between two adjacent crosslinks in a swollen hydrogel can be obtained ... 

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