Critical process

Fig. 12. Critical process parameters as a function of gas enthalpy where A is yield, B is concentration, and C is the specific energy requirement (SER).

Monitoring by Electromechanical Instrumentation. According to basic engineering principles, no process can be conducted safely and effectively unless instantaneous information is available about its conditions. AH sterilizers are equipped with gauges, sensors (qv), and timers for the measurement of the various critical process parameters. More and more sterilizers are equipped with computerized control to eliminate the possibiUty of human error. However, electromechanical instmmentation is subject to random breakdowns or drifts from caUbrated settings and requires regular preventive maintenance procedures. 

Combing is thus a critical process in producing a quaUty top. It is also a costiy process, and a modem comb wiU only produce at a maximum rate of about 30 kg/h for 21 p.m wool. 

The method can be used to monitor a process to indicate whether the corrosion rate is dependent on some critical process variable. 

Provide reliable and appropriate measurement of all critical process variables... 

The assessor should also find out whether an effective testing program is in place to help ensure the serviceability of process measurement equipment. The successful toller should have an established calibration program to address the accuracy of critical measurement equipment. Safety critical process parameters should be monitored and critical process equipment should automatically interlock when monitoring instrumentation detects safety critical deviations. Interlocks should either facilitate a remedy to the critical deviation or bring the process to the zero energy state. These instruments and interlocking devices should be routinely tested to ensure operational reliability. 

Phase 3 - Process Planning. The important design characteristics from Phase 2 are ranked with key process operations, where quantification yields actions to improve the understanding of the processes involved and gain the necessary expertise early on. The critical process operations highlighted are then carried forward to the next phase. 

Phase 4 - Production Planning. The critical process operations from Phase 3 are ranked with production requirement issues, ultimately translating the important customer requirements to production planning and establishing important actions to be taken. 

Before studying alternative types of equipment, we need to understand the critical process requirements. Is a solvent necessary Must products or by-products be removed to complete the reaction What mixing and/or time requirements are necessary Once again, early work up front is needed before alternate reaction schemes can be evaluated. 

The PRA procedures guide, NUREG/ CR-23(X), partitions human reliability analysis (HRA) into four phases (Figure 4.5-1). The familiarization phase, evaluates a sequence of events to identify human actions that directly affect critical process components. From plant visits and review, this part of HRA identifies plant-specific factors that affect human performance such as good or bad procedures used in the. sequence under consideration. The familiarization phase notes items overlooked during systems evaluation. 

Designate critical process alarms in the alkylation unit and ensure that these alarms are installed independent of equipment control loops... 

Although it is probably not possible at present to develop a completely satisfactory quantitative model, a conceptual model that identifies the critical processes can be developed. First, it is apparent that before significant chemical reaction can occur substantial modification must be induced by the shock-compression process. With present knowledge, the problem is one of mechanical deformation, rather than one of chemistry. The materials studies... 

A key advantage of the business process redesign approach is that while it draws on past experience (in the form of the team s collective expertise) it is not bound by it. This helps minimize the risk that inadequate practices may become institutionalized through habit or neglect, and forces the team to take a fresh look at the critical processes under review. At the same time, this approach requires more concentrated effort than either TQM or model programs and may not be necessary in cases where incremental improvement is all that s required to address PSM gaps. 

Checks of critical process parameters and warnings about hazardous conditions that can cause injury or equipment damage are important factors which determine the occurrence and recovery of human error. The purpose of these checks is to emphasize critical process information. Because of the critical nature of this information, checks and warning should be highlighted in a way that distinguishes them from other notes, and should be located where process workers will not overlook them. 

Confirm Measurement System > Baseline In-Process Product Parameters (Control, Capability) > Identify/Prioritize Process Steps > Identify Critical Process Parameters... 

ESH/PSM) critical processes or equipment—as may have been identified in hazard analyses. 

In order to illustrate the critical process parameters of SMB process validation, we will consider the separation of the racemic drug as described in Process design. The study represents the effect of the influence of feed concentration, number of plates and retention factor on the second eluting enantiomer. The simulation of the process for different values of feed concentration is performed and the variations of the extract and raffinate purities are shown in Fig. 10.10. 

Determine vacuum required at the critical process point in system. 

Inclusion of thermography into a predictive maintenance program will enable you to monitor the thermal efficiency of critical process systems that rely on heat transfer or retention electrical equipment and other parameters that will improve both the reliability and efficiency of plant systems. Infrared techniques can be used to detect problems in a variety of plant systems and equipment, including electrical switchgear, gearboxes, electrical substations, transmissions, circuit breaker panels, motors, building envelopes, bearings, steam lines, and process systems that rely on heat retention or transfer. 

The introduction of the sample into the adsorbent layer is a critical process in HPTLC. For most quantitative work a platinum-iridium capillary of fixed volume (100 or 200 nL), sealed into a glass support capillary of larger bore, provides a convenient spotting device. The capillary tip is polished to provide a smooth, planar surface of small area (ca 0.05 mm2), which when used with a mechanical applicator minimises damage to the surface of the plate spotting by manual procedures invariably damages the surface. 

Extensive studies have been reported with cisplatin in the field of chemoembolization (59,98). Microspheres prepared by a solvent evaporation procedure were characterized in vitro and critical processing parameters in regard to drug release kinetics were identified. 

Critical Process Sten Ciystal growth Lapping,Grlnding,Pollshing Slicing... 

Identification and evaluation of critical product and process parameters affecting Q attribute Allocating critical process steps (where)... 

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