COX-2 gene expression

Han M, Wen JK, Zheng B, Zhang DQ. Acetylbritannilatone suppresses NO and PGE2 synthesis in RAW 264.7 macrophages through the inhibition of iNOS and COX-2 gene expression. Life Sci 2004 75 675-684. 

Newton, R. et al. Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-lbeta. Biochem. Biophys. Res Commun. 237, 28, 1997. 

Lu, J., Ho, C.T., Ghai, G., and Chen, K.Y., Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells. Cancer Res., 60, 6465, 2000. 

Recent studies have shown that nitric oxide stimulates the synthesis of inflammatory prostaglandins by activating cyclooxygenase isoenzyme II (COX-2). Thus, inhibition of the nitric oxide pathway may have a beneficial effect on inflammatory diseases, including joint diseases. Studies using inhibitors of NOS-2 have shown that nitric oxide is required for maintaining COX-2 gene expression. 

Chen Y, Yang L, Lee TJ (2000) Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. Biochem Pharmacol 59(11) 1445-1457, S0006295200002550 [pii]... 

Inhibition of iNOS and COX-2 Gene Expression, but not iNOS and COX-2 Activities, by Wogonin, Oroxylin A and Quercetin... 

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