Coupled transcription coordinate

Transcription initiation by Pol 1, which synthesizes pre-rRNA, and by Pol 111, which synthesizes tRNAs, 5S rRNA, and other short, stable RNAs, has been characterized most extensively In S. cerevisiae using both biochemical and genetic approaches. It is clear that synthesis of tRNAs and of rRNAs, which are incorporated Into ribosomes, is tightly coupled to the rate of cell growth and proliferation. However, much remains to be learned about how transcription initiation by Pol I and Pol III is regulated so that synthesis of pre-rRNA, 5S rRNA, and tRNAs Is coordinated with the growth and replication of cells. 

This binuclear Zn(II) coordination complex in ZntR, coupled with the bound anion, was totally unexpected since Hg-MerR requires Just one trigonally coordinated Hg(II) ion that bridges the MerR dimer to effect metalloregulation of the /Her operon. The extent to which occupancy of one or both metal sites in each of two symmetry-related metal-binding loops in ZntR regulates transcriptional activation has yet to... 

S Additional information <228> (<228>, may function in a checkpoint control which couples DNA replication to mitosis. The level of the RPKl transcript is extremely low and constant throughout the mitotic cycle. However it is regulated during cellular differentiation, being decreased in a-factor-treated cells and increased late in meiosis in a diploids. Rpkl is involved in a pathway that coordinates cell proliferation and differentiation [417]) [417]... 

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