Coumarins muscle relaxants

Coumarins have been sought for the treatment of various types of acute muscle spasms associated with trauma and inflammation. Among these substances, chromonar hydrochloride is being used as a smooth muscle relaxant. 

More than two hundred pharmacologically unrelated compounds, when administered to animals enhance the activity of oxidative microsomal en mes and thus alter the duration and the intensity of drug action. For example, treatment of animals with phenobarbital decreases the hypnotic effect of subsequently administered hexobarbital. the muscle relaxant effect of zoxazolamine. the anticonvulsant activity of diphenylhydantoin, or the anticoagulant effect of bishydnn coumarin. This effect is blocked by co-administration of inhibitors of protein synthesis such as puromycin and actinomydn-D and is thought to result from de novo en me synthesis. Indeed, addition of the foreign compounds to microsomes in vitro does not increase enzyme activity and thus, activation of pre-existing enzyme can be ruled out. 

N.A. Hieracium pilosella L. Coumarin, umbelliferone, flavonoids, caffeic acid." Antifungal. Relax the muscles of the bronchial tubes, stimulate the cough reflex, reduce mucus. 

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