Cosolvency liquid drug preparations

For the preparation of a micellar solution, the water-insoluble drug and lipophilic excipients can be dissolved in a liquid surfactant by mixing at a relatively high temperature (43S 6flntil a clear solution is obtained. If necessary, a cosolvent can be added to aid solubility in the surfactant. Then a water or buffer solution containing hydrophilic excipients is added to the desired volume while mixing. In some cases, the aqueous solution needs to be heated to the same temperature as that > the surfactant to obtain desirable results. 

---