Corticosteroids anxiolytic effects

Andreatini R, Leite JR Evidence against the involvement of ACTH/CRF release or corticosteroid receptors in the anxiolytic effect of corticosterone. Braz J Med Biol Res 27(5) 1237-1241, 1994... 

Many attempts have been made to determine whether medications were influential as a risk factor. Although use of a prescription or nonprescription medication did not differ substantially between case patients and controls, it appeared that the use of an antidepressant or psychotropic medication (any antipsychotic, antidepressant, benzodiazepines, and/or other anxiolytic) could increase the risk of developing EMS.22-67 It is of interest that a number of medications, such as corticosteroids, oral contraceptives, and estrogen, which can alter tryptophan metabolism, have not been determined to have an effect on the development of EMS. Actually, some clinicians have postulated that EMS itself may be caused by or related to abnormal tryptophan metabolism.42 68... 

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