Corticoids with Multiple Modifications

5-acetate to give enone 26-5. The fluorine epimerizes in the process to form the favored equatorial 6a-fluoro epimer. 

Formation of a 2 bromo derivative by dehydrobromination requires, of course, the presence of an extra bromine at C2. This halogen is provided by a second bromination step to afford the dibromo derivative 26-6. Treatment of 

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