Correlation between o, x and

The experimental conditions that can be set up by the experimenter are [H]o and [G]o (see Eq. (2.8) and classification of variables). How should the experimental conditions, [H]o and [G]o, be changed for the titration There are so many possibilities described graphically in Fig. 2.6 containing a dilution experiment, a continuous variation experiment, a constant [H]o with different [G]o experiment and two more complicated examples. The criteria to decide the way of change might be as follows  

Let us consider how to choose the experimental conditions, [H]o and [G]o using a 1 1 host-guest complexation stoichiometry for simplicity. 

The steep rises of K at the complexation ratio ranges less than 20% and more than 80% cause the transfer of magnified errors from the complexation ratio into K. When K is determined based on the measurement of a property directly connected to or proportional to the complexation ratio, the obtained errors in K are magnified compared with those for the observed property. In the case where [H]o = 0.0001 M as an example, the complexation ratio is between 0.2 and 0.8 when K is between 3000 and 200 000 M , so an accurate experiment is carried out. This brief discussion shows, how the accuracy of K is governed by the choice of concentrations, [H]o, [G]o and also K itself. 

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